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Global Journal of Physical Chemistry. Volume 2, Issue 2 (2011) pp. 125-128
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Research Article
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Free Article
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Exosomes-biological liposomes as potential drug delivery agents
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Shivani Sharmaa,b, Viswanathan Palanisamyc, Cliff Mathisend, Michael Schmidtd, James K. Gimzewskia,b,e
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a Department of Chemistry and Biochemistry, University of California, Los Angeles, CA, USA
b California NanoSystems Institute, University of California, Los Angeles, CA, USA
c Department of Craniofacial Biology, MUSC College of Dental Medicine, Charleston, SC, USA
d FEI Company, 5350 NE Dawson Creek Dr., Hillsboro, OR, USA
e International Center for Materials Nanoarchitectonics Satellite (MANA),
National Institute for Materials Science (NIMS), Tsukuba, Japan
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Abstract |
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Exosomes are nanoparticles, secreted by wide range of normal mammalian cells and released into body fluids such as saliva, blood, urine, seminal plasma, amniotic fluid and breast milk. These naturally occurring nano-vesicles possess structural, mechanical and biological characteristics. We report the characteristic exosome morphology via high resolution FESEM (round vesicles 70-100nm) and quantify nanomechanical properties of exosomes (Young's modulus E= 88.9 ± 7.4 KPa) at the single vesicle level using Atomic Force Microscopy. The findings suggest the potential role of exosomes towards development of advanced drug delivery and gene therapy applications.
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Keywords |
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Nanoparticles; Exosomes; Membrane vesicles; Mechanics; Atomic Force Microscopy
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