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  Global Journal of Analytical Chemistry. Volume 1, Issue 3 (2010) pp. 189-195
  Research Article
Quantifying chiral selectivity of Metoprolol using Carboxymethylated ß-Cyclodextrin in Capillary Electrophoresis
  Marta Painous Boscha,b, Jetse C. Reijengab*  
a Department of Physical and Inorganic Chemistry, University of Tarragona, Campus Sescelades, 43007 Tarragona, Spain
b Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands

  Chiral separation of optical isomers of ß-blocker Metoprolol was quantitatively investigated and modelled using un-modified and 2-O-carboxymethylated ß-Cyclodextrin as chiral selector, added to the background electrolyte. Interaction constants and complex mobilities were determined with both selectors, and as a function of temperature in the range 20-50 ºC. Interaction constants at 20 ºC were 342 and 972 respectively. Thermodynamic parameters were also determined. The chiral selectivity was both enthalpy and entropy driven. For accurately determining interaction constants, the need for ionic strength correction, and the effect of temperature and driving voltage was critically evaluated and results were compared with higher ionic strength buffers.
  Capillary Electrophoresis; Chiral selectivity; Carboxymethylated ß-Cyclodextrin; Metoprolol; ß-Blockers  

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