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  Global Journal of Surgery 2012, 3: 13
  Research Article
PERI - incisional infiltration of metronidazole in open appendectomy: A meta-analysis
  Raul Guillermo Lopez-Valle, Cristela Hernandez  
Mcallen Family Medicine Residency, University of Texas Health Science Center San Antonio, Mcallen, TX
  Introduction: Appendicitis is the most common acute condition of the abdomen requiring surgery. overall, it is still associated with a relatively high percentage of wound sepsis, which is determined primarily by the grade of appendicitis. The objective of this paper is determine whether peri-incisional infiltration of metronidazole reduces wound sepsis after open appendectomy. Methods: A literature search was performed for all studies published, reporting on open surgery for appendicitis. Results: Five studies fulfilled the inclusion criteria, evaluating 695 patients: treatment group=315, control group=380. a meta-analysis of these studies showed a significantly reduced incidence of wound infection (treatment group=2.54%, control group=12.93%, odds ratio = 0.129 [0.059 - 0.282], arr=10.35% [ci 95% 6.56 – 14.14%] and nnt= 9.7 [ci 95% 7.1 – 15.2]). Conclusions: PERI-incisional infiltration of metronidazole significantly reduced the rate of wound sepsis in open appendectomy.
  Metronidazole; Wound sepsis; PERI-incisional; Acute appendicitis  

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