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  Global Journal of Surgery 2012, 3: 16
  Research Article
The role of Platelet-Rich Plasma (PRP) in the treatment of knee problems
  E. C. Rodriguez-Merchan  
Department of Orthopaedic Surgery, La Paz University Hospital, Paseo de la Castellana 261, 28046-Madrid, Spain
  The use of platelet-rich plasma (PRP) is becoming increasingly available. PubMed articles related to the use of PRP in knee problems were searched using the following key words: PRP and knee. A total of 43 reports were found. Many of them were animal studies and the rest were human clinical studies with no controls. The review of the literature showed four main potential roles of PRP in knee problems: soft tissue healing (ACL injuries, patellar tendinosis – jumper´s knee, synovitis, meniscal tears, wound healing), bone healing or regeneration, cartilage injuries and osteoarthritis, and intraoperative use during total knee arthroplasty (TKA). The aforementioned animal experiments and clinical studies have suggested that placement of a collagen-PRP bridging scaffold in a central ACL defect could stimulate healing of the ACL histologically and biomechanically. Also that PRP injections could have the potential to promote the achievement of a satisfactory clinical outcome in cases of jumper´s knee. PRP could also be beneficial to the alleviation of synovitis. PRP could enhance the healing of meniscal defects as well. Treatment of wounds with PRP gel could induce accelerated epithelial differentiation. Percutaneous injection of a mixture of PRP and MSCs (mesenchymal stem cells) transplantation could be more effective on bone non-union than the traditional treatment. Intra-articular injections of PRP could have preventive effects against OA progression. Patients receiving platelet gel during TKA could have less postoperative blood loss and less narcotic requirement. However, PRP is a treatment that is still experimental and in many instances shown to be not significant in its effects.
  Platelet-Rich Plasma (PRP); Knee  

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