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  Global Journal of Biochemistry. Volume 1, Issue 1 (2010) pp. 68-78
  Review Article Free Article
Cancer as a developmental disease: Lessons from cancer stem cells
  Tessy Thomas Maliekala, Jeevisha Bajajb  
a Integrated Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Thriuvananthapuram-695014, India
b National Centre for Biological Sciences, Tata Institute of Fundamental Research, UAS-GKVK Campus, Bangalore-560 065, India

  A normal cell becomes a malignant cell when it stops to respond to growth arresting and differentiating signals and leads to uncontrolled proliferation. When we analyze the development of an organism and malignancy it is evident that the processes involve same basic mechanism except that in malignancy the cells cease to respond to normal controlling signals. Even though the existence of a stem like population in cancer was suggested long back, the evidence of cancer stem cells came much later. This review projects cancer stem cells as an aberrant cell evolved from normal stem cell and provides a comparison of their markers and characteristics. Further, we discuss the information gathered from the mouse models that explain carcinogenesis and the possible generation of cancer stem cells.
  Cancer stem cells; Stem cells; CD133; Leukemia; Breast cancer  

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