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  Global Journal of Biochemistry. Volume 2, Issue 3 (2011) pp. 205-214
  Review Article Free Article
Fundamental properties of ERK1 and ERK2
  Toshiya Teraishia,#, Kenji Miurab  
a Department of Psychiatry, National Defense Medical College, Tokorozawa, Saitama 359-8513, Japan
b Department of Developmental Anatomy and Regenerative Biology, National Defense Medical College Tokorozawa, Saitama 359-8513, Japan

  Mitogen-activated protein (MAP) kinase cascade is three-layer signaling system to transmit extracellular signals into nucleus, which responds to stimulus suitably and to keep homeostasis of cells, tissues and organisms. Extracellular signal-regulated kinase 1 (ERK1) and extracellular signal-regulated kinase 2 (ERK2) are representative members of MAP kinase superfamily and are in terminal layer of three-layer MAP kinase cascade. They play crucial roles in organisms, development, management of cell cycle progression, cell proliferation and apoptosis. They are ubiquitously distributed in almost all kinds of organs or tissues of individual bodies through many kinds of species. Here, we compiled fundamental molecular information of ERK1 and ERK2. We also described how vast kinds of species ERK1/2 work in and how widely ERK1/2 is distributed in organs or tissues of individual bodies.
  Extracellular signal-regulated kinase; ERK1/2; MAP kinase; Molecular profile; Immunohistochemistry; Phosphorylation  

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