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  Global Journal of Biochemistry 2012, 3: 2
  Review Article Free Article
 
Potential role of cxc chemokines and their respective receptors in pathogenesis of triple negative breast cancer
  Jin-Qiang Chena,b, Jose Russoa  
     
a Breast Cancer Research Laboratory, Fox Chase Cancer Center, 333 Cottman Avenue Philadelphia, PA, USA 19111,
b GoldBelt Falcon-LLC 860 Greenbrier Circle, Suite 410, Chesapeake, VA, 23360, U.S.A

   
  Abstract  
  Triple negative breast cancer (TNBC) is negative for estrogen receptor ? (ER?), progesterone receptor (PR) and human epithelial growth factor receptor-2 (HER-2). TNBC exhibits high-grade histology, more aggressive clinical behavior, early development of recurrence, high distant metastases to bone, lung and brain and a poor survival. The molecular mechanisms underlying these clinical and pathological features of TNBC have not been well defined. In the present work, we present evidence to indicate the potentially important roles of CXC chemokines and their respective receptors in the pathogenesis of TNBC with special relation to the aggressive clinical behavior. We also described the application of several types of inhibitors targeting CXCL8-CXCR1/CXCR4 and CXCL12-CXCR4 axis as potential therapeutic strategies for TNBC.
     
  Keywords  
  Triple negative breast cancer; CXC chemokines; CXCL8; CXCL12/SDF-1; CXCR1, CXCR2; CXCR4  
     
   
   
   
   
     

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