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  Physics Express 2012, 2: 6
  Research Article
 
Experimental study and modeling of tissue plasminogen activators release encapsulated by chitosan coated poly (lactide-co-glycolide acid) nanoparticles
  Mahboobeh Mahmoodia,b, Mohammad E. Khosroshahia, Fatemeh Atyabic, Afrooz Saadat zadeh c  
     
a Laser and Nanobiophotonics Lab, Biomaterial Group, Faculty of Biomedical Engineering AmirkabirUniversity of Technology, Tehran, Iran
b Islamic Azad University of Yazd, Faculty of Eng., Material Group, ,Yazd, Iran
c Novel Drug Delivery Systems Lab, Faculty of Pharmacy, Medical Sciences University of Tehran, Iran

   
  Abstract  
  The purpose of this study is to prepare cationic nanoparticles by coating chitosan (CS) on the surface of PLGA nanoparticles. In vitro tPA release experiments encapsulated by PLGA and PLGA/CS nanoparticles are determined by HPLC and showed a sustained release profile for three days in both case and with a little initial burst release of tPA from PLGA/CS nanoparticles. The mean particle size and encapsulation efficiency of tPA nanoparticles were in the range of 280-360 nm and 46.7% ±1.56, 50.8% ±1.09 for PLGA and PLGA/CS nanoparticles, respectively. The encapsulation efficiency and the particles size were increased as a result of coating with CS. The release kinetics was evaluated by fitting the experimental data to standard release equations (Riger-Peppas equation and Higuchie equation). Both models were used to find the best fit for NPs.
     
  Keywords  
  Chitosan; Tissue plasminogen activator (tPA); W/O/W solvent evaporation; Nanoparticles; Drug delivery  
     
   
   
   
   
     

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