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Physics Express 2012, 2: 6
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Research Article
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Experimental study and modeling of tissue plasminogen activators release encapsulated by chitosan coated poly (lactide-co-glycolide acid) nanoparticles
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Mahboobeh Mahmoodia,b, Mohammad E. Khosroshahia, Fatemeh Atyabic, Afrooz Saadat zadeh c
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a Laser and Nanobiophotonics Lab, Biomaterial Group, Faculty of Biomedical Engineering AmirkabirUniversity of Technology, Tehran, Iran
b Islamic Azad University of Yazd, Faculty of Eng., Material Group, ,Yazd, Iran
c Novel Drug Delivery Systems Lab, Faculty of Pharmacy, Medical Sciences
University of Tehran, Iran
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Abstract |
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The purpose of this study is to prepare cationic nanoparticles by coating chitosan (CS) on the surface of PLGA nanoparticles. In vitro tPA release experiments encapsulated by PLGA and PLGA/CS nanoparticles are determined by HPLC and showed a sustained release profile for three days in both case and with a little initial burst release of tPA from PLGA/CS nanoparticles. The mean particle size and encapsulation efficiency of tPA nanoparticles were in the range of 280-360 nm and 46.7% ±1.56, 50.8% ±1.09 for PLGA and PLGA/CS nanoparticles, respectively. The encapsulation efficiency and the particles size were increased as a result of coating with CS. The release kinetics was evaluated by fitting the experimental data to standard release equations (Riger-Peppas equation and Higuchie equation). Both models were used to find the best fit for NPs.
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Keywords |
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Chitosan; Tissue plasminogen activator (tPA); W/O/W solvent evaporation; Nanoparticles; Drug delivery
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