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  Chemical Sensors 2011, 1: 19
  Research Article
Functionalized ZnO nanotube arrays for the selective determination of uric acid with immobilized uricase
  Syed M. Usman Ali, Zafar H. Ibupoto, C.O. Chey, Omer Nur, Magnus Willander  
Physical Electronics and Nanotechnology Division, Department of Science and Technology, Campus Norrköping, Linköping University, SE-60174 Norrköping, Sweden
  In this paper, we have demonstrated a highly sensitive and stable uric acid sensor based on the highly oriented single-crystal ZnO nanotubes (ZnO-NTs) fabricated on the surface of gold coated glass substrate in an aqueous solution. The prepared (ZnO-NTs) arrays were further used as a working electrode to fabricate an enzyme-based uric acid biosensor through immobilizing uricase enzyme by physical adsorption method in conjunction with a Nafion membrane. The electrochemical response of the developed sensor is found to be linear over a relatively wide logarithmic concentration range from 500 nM to 1500 µM and the sensitivity of the proposed sensor is found to be ~68 mV/decade. Compared with the biosensors based on the nanowires, the proposed biosensor shows expanded linear range and sensitivity. Moreover, its experimental detection of limit is 500 nM with fast response time, good selectivity, reproducibility and good anti-interference performance to common interferents such as ascorbic acid, glucose and urea.
  ZnO nanotubes; Electrochemical nanodevices; Uricase; Uric acid; Nanostructured modified biosensor  

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