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  Chemical Sensors 2011, 1: 20
  Review Article
Nanocomposites for implantable nanosensors in biomedical applications
  Vasilios N. Psychoyiosb, Georgia-Paraskevi Nikolelib, Dimitrios P. Nikolelisa, Nikolaos Tzamtzisb  
a Laboratory of Environmental Chemistry, Department of Chemistry, University of Athens, Panepistimiopolis-Kouponia, 15771 Athens, Greece
b Laboratory of Inorganic and Analytical Chemistry, School of Chemical Engineering, Dept 1, Chemical Sciences, National Technical University of Athens, 9 Iroon Polytechniou St., Athens 157 80, Greece

  Nanosensors based on structural and functional properties of synthetic polymers, have emerged in the last decade as an efficient strategy for implantation in medical applications. A wide range of polymers, such as the aliphatic polyesters polylactide (PLA), poly(glycolides) (PGA), poly(e-caprolactone) (PCL), have attracted wide attention for their biodegradability and biocompatibility in the human body. The introduction of microfillers into biodegradable polymers to produce nanostructures, in order to prepare new biomaterials with enhanced properties recently improved this technology. Work on improving the interfacial adhesion between the polymer and the nanostructures has become the key technique in the nanocomposite processing. In the present review, the fabrication of nanocomposites based on biodegradable polymers for the construction of nanosensors that can be implanted and have a wide range of medical applications is presented. The combination of bioabsorbed polymers with nanotechnology opens new perspectives in emerging nanomaterials in the biomedical application technology that opens new routes in life science.
  Biosensors; Biocompatibility; Implantable; Nanofabrication; Medical applications  

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