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Chemical Sensors 2012, 2: 5
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Research Article
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Simultaneous electroanalysis of epinephrine, ascorbic acid and uric acid at
SDS modified carbon paste electrode: A cyclic voltammetric study
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B. N. Chandrashekara, B. E. Kumara Swamya, K. J. Gururaja, S. Chitravathia, M. Pandurangacharb
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a Department of P. G. Studies and Research in Industrial Chemistry, Kuvempu University, Shankaraghatta -577 451, Shimoga, Karnataka, India
a Department of Chemistry, NMKRV College for Women with Degree, PG and Research Centre (Autonomous), Jayanagar 3rd Block, Bengaluru-11, Karnataka, India
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Abstract |
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The sodium dodeceyl sulphate (SDS) modified carbon paste electrode (SDS/CPE) was applied for sensitive and selective voltammetric determination of epinephrine (EN), ascorbic acid (AA) and uric acid (UA). They are compounds of great biomedical interests, playing determining roles in human metabolism. The objective of this novel modified electrode was to seek the new electrochemical approach for the detection of EN, AA and UA. This modified electrode showed an excellent electrocatalytic activity towards the oxidation of EN with accelerated electron transfer rate with an increase in anodic peak current as compared to the process at an unmodified electrode. The SDS/CPE exhibited linear range for the calibration curve of EN concentration (10 μA to 70 μA) with R2=0.9987. The SDS/CPE exhibited potent and persistent electrochemical interaction behavior followed by well-separated EN, AA and UA cyclic voltammetric oxidation waves (0.16, 0.016 and 0.3 V) observed at neutral pH phosphate buffer solution. The detection limit of EN was found to be 5.0×10-7 M. The surface characterization of the SDS/CPE was done by scanning electron microscopy (SEM) and cyclic voltammetric technique. Due to the good electrocatalytic activity of the modified electrode, it could also be applied to the determination of EN in pharmaceutical samples and the results obtained were found to be satisfactory.
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Keywords |
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Epinephrine; Cyclic voltammetry; Phosphate buffer; SDS/CPE
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