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  Chemical Sensors 2012, 2: 15
  Review Article
 
Glassy carbon electrode modified with functionalized multiwalled carbon nanotubes within a poly(allylamine hydrochloride) film for the determination of propylthiouracil in pharmaceuticals by cathodic stripping voltammetry
  Geiser Gabriel Oliveiraa, Elen Romão Sartoria,b, Fabiana Yukari Tanakaa, Orlando Fatibello-Filhoa,c  
     
a Departamento de Química, Universidade Federal de São Carlos, C.P. 676, 13560-970, São Carlos – SP, Brazil
b Departamento de Química, Universidade Estadual de Londrina, C.P. 6001, 86051-990, Londrina – PR, Brazil
c Instituto Nacional de Ciências e Tecnologia em Bioanalítica, 13083-970, Campinas – SP, Brazil

   
  Abstract  
  A glassy carbon electrode modified with multiwalled carbon nanotubes within a poly(allylamine hydrochloride) film was used for the determination of propylthiouracil in pharmaceutical formulations. The obtained cyclic voltammogram showed an anodic peak at 0.684 V (vs. Ag/AgCl (3.0 M KCl)) and a cathodic peak at –0.088 V of the oxidation product adsorbed on the electrode surface. Applying an accumulation potential of 1.0 V for 60 s, the propylthiouracil was determined by using a cathodic stripping voltammetry at 200 mV s–1. The analytical curve obtained was linear in the propylthiouracil concentration from 5.0 to 58.0 ?M in a Britton-Robinson buffer solution (pH 2.0), with a detection limit of 1.0 µM. The proposed method was successfully applied for the determination of propylthiouracil in pharmaceutical formulations.
     
  Keywords  
  Propylthiouracil; Stripping voltammetry; Modified electrode; Multiwalled carbon nanotubes; Poly(allylamine hydrochloride)  
     
   
   
   
   
     

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