|
|
|
| |
World's one of the largest Research
Career Network |
|
|
|
Benefits |
- Academic & Industry jobs
- Project funding
- Visiting faculty positions
- Visiting scientist positions
- Invited talks
- and more...
|
|
|
|
|
|
|
|
Register FREE
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Chemical Sensors 2012, 2: 15
|
|
|
Review Article
|
|
|
|
|
|
|
Glassy carbon electrode modified with functionalized multiwalled carbon nanotubes within a poly(allylamine hydrochloride) film for the determination of propylthiouracil in pharmaceuticals by cathodic stripping voltammetry
|
|
|
|
Geiser Gabriel Oliveiraa, Elen Romão Sartoria,b, Fabiana Yukari Tanakaa, Orlando Fatibello-Filhoa,c
|
|
|
|
|
|
|
|
a Departamento de Química, Universidade Federal de São Carlos, C.P. 676, 13560-970, São Carlos – SP, Brazil
b Departamento de Química, Universidade Estadual de Londrina, C.P. 6001, 86051-990, Londrina – PR, Brazil
c Instituto Nacional de Ciências e Tecnologia em Bioanalítica, 13083-970, Campinas – SP, Brazil
|
|
|
|
|
|
|
|
Abstract |
|
|
|
A glassy carbon electrode modified with multiwalled carbon nanotubes within a poly(allylamine hydrochloride) film was used for the determination of propylthiouracil in pharmaceutical formulations. The obtained cyclic voltammogram showed an anodic peak at 0.684 V (vs. Ag/AgCl (3.0 M KCl)) and a cathodic peak at –0.088 V of the oxidation product adsorbed on the electrode surface. Applying an accumulation potential of 1.0 V for 60 s, the propylthiouracil was determined by using a cathodic stripping voltammetry at 200 mV s–1. The analytical curve obtained was linear in the propylthiouracil concentration from 5.0 to 58.0 ?M in a Britton-Robinson buffer solution (pH 2.0), with a detection limit of 1.0 µM. The proposed method was successfully applied for the determination of propylthiouracil in pharmaceutical formulations.
|
|
|
|
|
|
|
Keywords |
|
|
|
Propylthiouracil; Stripping voltammetry; Modified electrode; Multiwalled carbon nanotubes; Poly(allylamine hydrochloride)
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|