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  Chemical Sensors 2013, 3: 17
  Review Article
Hemoglobin biosensor based on reduced graphite oxide modified gold electrode array printed on paper
  Xueping Danga,b,c, Jinou Zhengb, Chengguo Hub,c, Shengfu Wanga, Shengshui Hub,c  
a Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Hubei University, Wuhan 430062, P. R. China
b Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China
c State Key Laboratory of Transducer Technology, Chinese Academy of Sciences, Beijing 10080, P. R. China

  Nanoporous gold electrode arrays on cellulose membranes were prepared by an inkjet printing technique, on which hemoglobin (Hb) was incorporated in chitosan-reduced graphene oxide (CHIT-rGO) composite films for biosensing. A pair of well-defined voltammetric peaks was obtained on this paper-based electrochemical sensor, revealing the direct electron transfer of Hb. Scanning electron microscopy (SEM) and reflectance absorption infrared (RAIR) spectroscopy demonstrated that Hb molecules were successfully immobilized in the CHIT-rGO nanocomposite and remained their native secondary structure. The immobilized Hb showed excellent biocatalytic activity to the reduction of nitric oxide (NO) and hydrogen peroxide (H2O2), which can be used for the sensitive determination of these species. The employment of cellulose-based paper as electrode support, together with the unique properties of the gold arrays like easy fabrication and low cost, foresaw the promising applications of this paper-based gold array in developing disposable and environment-friendly electrochemical biosensors.
  Inkjet printing; Paper-based electrode arrays; Graphene oxide; Hemoglobin; Biosensor  

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