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  Chemical Sensors 2013, 3: 19
  Research Article
Three-dimensional CuO nanoflowers for electrochemical detection of glucose and other carbohydrates in neutral medium
  Yuchan Zhanga,b,Yixin Liub, Hui Huangc, Liang Sub,Danqun Huoa, Steven L. Suibc, Changjun Houa,and Yu Leib  
a Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400030, China
b Department of Chemical, Materials and Biomolecular Engineering, University of Connecticut, 191 Auditorium Road, Unit 3222, Storrs, Connecticut 06269, USA
c Department of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, Unit 3020, Connecticut 06269, USA

  Three-Dimensional (3-D) CuO nanoflowers (CuO NFs) were synthesized and applied to construct a non-enzymatic sensor for the detection of glucose and other carbohydrates in neutral solution. The electrochemical property of 3-D CuO NFs in neutral pH environment was first investigated by cyclic voltammetry in the absence and presence of glucose. It is interesting to find that the oxidation/reduction peaks of CuO NFs were significantly suppressed in the presence of glucose and the suppression of peak current showed a concentration-dependent behavior, thus providing a new sensing platform for glucose and other carbohydrates detection in neutral pH solution. The investigation of the sensing mechanism using electrochemical impedance spectroscopy and equivalent circuit model reveals that the suppression of oxidation/reduction peaks of CuO NFs in the presence of target could be ascribed to the specific adsorption of glucose on CuO NFs, which results in the significant change of adsorption resistance. Differential pulse voltammetry was further applied to detect glucose in pH 7.0 solution, which shows a wide dynamic range and good selectivity against uric acid and ascorbic acid. The application of CuO NFs for the detection of other carbohydrates in neutral pH was also demonstrated. These features implicate the potential applicability of 3-D CuO NFs in non-enzymatic glucose and other carbohydrates detection in neutral medium.
  3-D CuO nanoflowers; Non-enzymatic; Glucose detection; Adsorption; Neutral medium; Carbohydrates  

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