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  Journal of Nanoscience Letters. Volume 1, Issue 3 (2011) pp. 172-178
  Research Article
Glucose stabilized ZnO nanoparticles for biomedical applications
  N. Naga, A. Bhattacharyaa, R.K. Guptaa, K. Manivannana, P. K. Kahola, A. K. Wanekayab R. K. Delongc, K. Ghosha  
a Department of Physics, Astronomy, and Materials Science, Missouri State University Springfield MO 65897, U.S.A
b Department of Chemistry, Missouri State University, Springfield, MO 65897, U.S.A
c Department of Biomedical Science, Missouri State University, Springfield, MO 65897, U.S.A

  In this paper we report a novel approach for the synthesis of stable ZnO nanoparticles in aqueous media using pulsed laser deposition technique. These particles have been characterized using UV-Vis spectroscopy, fluorescence spectroscopy (FS), transmission electron microscopy (TEM), and dynamic light scattering (DLS) spectroscopy. UV-Vis study confirmed the existence of ZnO nanoparticles showing a peak at around 280 nm which is consistent with the absorption spectra of standard ZnO nanoparticles. Presence of ZnO is reconfirmed by the excitation and emission spectra obtained from FS. Particle size measurement by DLS and TEM demonstrated that a nearly monodispersed nanoparticle suspension has been prepared. Increased aggregation over time of ZnO nanoparticles is inhibited successfully by surface modification with glucose, and optimum glucose concentration is determined. Finally, it has also been demonstrated by UV-Vis spectroscopy that the surface modified ZnO nanoparticles are capable of binding with protein bovine serum albumin which is further confirmed by DLS spectroscopy experiments.
  Nanomaterials; Oxide Nanoparticles; Binding and Stability of nanoparticles; Pulsed Laser Deposition  

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