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  Journal of Nanoscience Letters 2012, 2: 24
  Research Article
Potentiometric creatinine biosensor based on ZnO nanowires
  Chan Oeurn Cheya,b, Syed M. Usman Alia, Zafar H. Ibupotoa, Kimleang Khuna,b, Omer Nura, Magnus Willandera  
a Physical Electronics and Nanotechnology Division, Department of Science and Technology, Campus Norrköping, Linköping University, SE-60174 Norrköping, Sweden
b Physics Department, Faculty of Science, Royal University of Phnom Penh, Cambodia

  In the present work, we have grown well-aligned zinc oxide (ZnO) nanowires (NWs) on the surface of gold coated glass substrates by a low temperature aqueous chemical growth (ACG) approach and utilized it as a potentiometric creatinine biosensor. This was achieved by electrostatic immobilization of creatinine deiminase (CD) on the surface of the ZnO NWs followed by applying a chitosan membrane in conjunction with glutaraldehyde. This immobilization resulted in a sensitive, selective, stable, reproducible and fast creatinine biosensor. The potentiometric response of the ZnO sensor vs. Ag/AgCl reference electrode was found to be linear over a wide logarithmic concentration of creatinine electrolyte solution ranging from 1-1000 µM. The sensor illustrates good linear sensitivity slope curve of ~33.9 mV/decade along with a rapid response time of ~7 s. Furthermore, the sensor response was unaffected by normal concentrations of common interferences such as potassium, calcium, magnesium, sodium, copper ions and glucose.
  ZnO nanowires; Potentiometric nanosensor; Electrochemical nanodevices; Creatinine deiminase; Creatinine  

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