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Journal of Nanoscience Letters 2013, 3: 5
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Research Article
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Biosynthesis of titanium nanoparticles and their role in killing colon cancer cells
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Praseetha P. Ka, Supriya C. Vb, Chandraja C. Vb, Vijayalekshmi Bc, Murthy S. Chavalia
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a Department of Nanotechnology, Noorul Islam Centre for Higher Education, Kumaracoil, Kanyakumari District, Tamil Nadu
b Department of Microbiology, Noorul Islam College of Arts and Science. Kumaracoil, Kanyakumari District, Tamil Nadu
c` Department of Chemistry, Noorul Islam Centre for Higher Education, Kumaracoil, Kanyakumari District, Tamil Nadu
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Abstract |
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Bioconjugation of nanoparticles with anticancer drugs is an important method of targeted drug therapy. Currently drugs are conjugated artificially onto nanoparticles for targeted delivery. Here we report the results of cancer cytotoxicity of biosynthesized nanoparticles naturally laden with anticancer drugs. During biosynthesis, the titanium nanoparticles are bioconjugated with anticancer biomolecules capable of killing cancer cells. The biosynthesized nanotitanium when exposed to UV radiation reduces the proliferation of cancer cells manifold by apoptosis.
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Keywords |
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Biosynthesis; Nanotitanium; Anticancer proteins; Actinomycetes; Colon cancer
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