|
|
|
| |
World's one of the largest Research
Career Network |
|
|
|
Benefits |
- Academic & Industry jobs
- Project funding
- Visiting faculty positions
- Visiting scientist positions
- Invited talks
- and more...
|
|
|
|
|
|
|
|
Register FREE
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Journal of Nanoscience Letters 2013, 3: 29
|
|
|
Research Article
|
|
|
|
|
|
|
Investigation of cumulative release of insulin from swellable calcium pectinate nanocarriers
|
|
|
|
Shilpi Goswami, Jaya Bajpai, A. K. Bajpai
|
|
|
|
|
|
|
|
Bose Memorial Research Laboratory, Department of Chemistry, Government Autonomous Science College, Jabalpur (MP) - 482001, India
|
|
|
|
|
|
|
|
Abstract |
|
|
|
Oral delivery of insulin is a challenging and unresolved problem until now. The present work aims at investigating controlled release of insulin so as to translate it to a possible and feasible approach for oral drug delivery. In the present study nanoparticles of calcium pectinate have been synthesized via emulsion crosslinking technique. In this technique aqueous and oil phase solutions were mixed together with vigorous shaking and then the cross-linker was added to this solution with continuous stirring. The prepared nanoparticles were characterized by FTIR, transmission electron microscopy, dynamic light scattering and zeta potential measurements. The nanoparticles were allowed to swell in phosphate buffer saline (PBS) and the influence of factors, such as chemical composition of nanoparticles, pH and temperature of the swelling bath were investigated on the water intake capacity of the pectin nanoparticles. The effects of the insulin loading percentage were examined. The structural integrity of insulin loaded nanoparticles was also assessed by UV spectral study especially under highly acidic conditions mimicking artificial gastric juice.
|
|
|
|
|
|
|
Keywords |
|
|
|
Nanoparticles; Drug release; Kinetics; Swelling; Controlled release; Polymer nanoparticles; Insulin
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|