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  Journal of Spectroscopy and Dynamics 2011, 1: 2
  Research Article
Ultrafast 2D NMR applied to the kinetic study of D-glucose mutarotation in aqueous solution
  Patrick Giraudeau*, Pauline Lemeunier, Mathieu Coutand, Jean-Marie Doux, Alexis Gilbert, Gérald S. Remaud, Serge Akoka  
Université de Nantes, CNRS, Chimie et Interdisciplinarité : Synthèse, Analyse, Modélisation (CEISAM) UMR 6230, B.P. 92208, 2 rue de la Houssinière, F-44322 Nantes Cedex 03, France
  Two-dimensional Nuclear Magnetic Resonance (2D NMR) is hampered by long acquisition times. Consequently, 2D NMR is ill-suited for the study of short timescale phenomena such as kinetic studies or dynamic processes. Fortunately, ultrafast 2D NMR makes it possible to record a 2D NMR correlation in a single scan, and is therefore adapted to real-time studies of fast occurring processes. Here, we describe the application of heteronuclear ultrafast 2D NMR to the kinetic study of D-glucose mutarotation at natural abundance in non-deuterated water. Mutarotation constants are determined with a 10 % precision. The results presented in this paper are a new illustration of the potentialities of ultrafast 2D NMR for real-time kinetic studies.
  2D NMR; Ultrafast NMR; HSQC; Kinetics; Mutarotation; Glucose  

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