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Journal of Spectroscopy and Dynamics 2012, 2: 16
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Research Article
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A phantom replacement method for in vivo Phosphorus-31 magnetic resonance spectroscopic imaging data
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Jonathan A. Dudleya,c, Elizabeth M. Fugateb,c, Wen-Jang Chub,c, Stephen M. Strakowskia,b,c, Jing-Huei Leea,b,c
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a School of Energy, Environmental, Biological, and Medical Engineering, 2901 Woodside Drive, 601 Engineering Research Center,
University of Cincinnati, Cincinnati OH, USA 45220
b Department of Psychiatry and Behavioral Neuroscience, 260 Stetson Street, Suite 3200,
University of Cincinnati, Cincinnati OH, USA 45221
c Center for Imaging Research, 231 Albert Sabin Way, Suite E6585 MSB,
University of Cincinnati, Cincinnati OH, USA 45267-0583
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Abstract |
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The validity of a phantom replacement (i.e. external reference) method of phosphorous metabolite quantification is examined by using an internal reference method. Phosphorus-31 magnetic resonance spectroscopic imaging (31P MRSI) data were collected from the whole head of twenty subjects. Phosphorus-31 MRSI external reference data were acquired from a 2.5-liter spherical phantom containing a 50 mM solution of inorganic phosphate (KH2PO4). Internal reference data were acquired from the anterior cingulate and left ventral lateral prefrontal cortices of all twenty subjects via single voxel proton (1H) MRS. Statistical analyses found no differences between the phantom replacement method and1H MRS internal referencing. The results suggest that phantom replacement can be used for in vivo 31P MRS/MRSI quantification studies.
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Keywords |
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Phosphorus spectroscopy; Quantification; Phantom replacement; External reference; Internal reference
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