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Journal of Spectroscopy and Dynamics 2013, 3: 1
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Research Article
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Pressure-tuning infrared and Raman studies of polymorphism in pharmaceutical compounds: Progesterone
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Gisia L. Pisegna, Ian S. Butler
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Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec, Canada H3A 2K6
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Abstract |
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The IR and Raman spectra of the two polymorphic forms, I and II, of progesterone (pregn-4-ene-3,20-dione) have been examined under high pressures up to about 50 kbar using a diamond-anvil cell. Both polymorphs undergo structural changes in the 15-20 kbar pressure range. There is no convincing evidence for the conversion of form II into the more thermodynamically stable form I.
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Keywords |
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Polymorphism; Pharmaceutical compounds; High pressure; Diamond-anvil cell; IR and Raman spectroscopy
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