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Sci. Lett. J. 2015, 4: 179
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Research Article
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Full Text
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Novel methodology for the detection of circulating tumor cells in gastric cancer and cell-free nucleic acids in gastrointestinal malignancies
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Hiroaki Itoa, Katsuyuki Hasegawab, Yuuki Hasegawab, Satoshi Kimurac, Manabu Onimarua, Noriko Yamaguchid, Haruo Ikedaa, Mitsuo Saitoa, Haruhiro Inouea
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a Digestive Disease Center, Showa University Koto Toyosu Hospital, 5-1-38 Toyosu, Koto-ku, Tokyo 135-8577, Japan
b HI-DEC Kobe 101, 6-7-4 Minatojimaminamimachi, Kobe Chuo-ku, Hyogo 650-0047, Japan
c Department of Laboratory Medicine and Central Clinical Laboratory, Showa University Northern Yokohama Hospital, 35-1 Chigasakichuo, Tsuzuki-ku, Yokohama 224-8503, Japan
d Digestive Disease Center, Showa University Northern Yokohama Hospital, 35-1 Chigasakichuo, Tsuzuki-ku, Yokohama 224-8503, Japan
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Abstract |
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The detection of circulating tumor cells in peripheral blood is useful for estimating the prognosis of cancer patients. We have previously shown that the number of circulating tumor cells significantly correlates with the prognosis of treatment-naive gastric cancer patients. However, whether all GFP-positive circulating tumor cells have true metastatic potential was unclear. Therefore, we developed a simple and rapid methodology using surface-enhanced Raman scattering with silver nano-hexagonal columns. We successfully implemented this method in blood tests for cancer screening and detection of unknown serum-constituents that are cancer-related biomarkers.
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Keywords
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Circulating tumor cells; Cell-free nucleic acids; Silver nano-hexagonal column; Cancer
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